Population pharmacokinetics of artemether , lumefantrine and their 1 respective metabolites in Papua New Guinean children with uncomplicated 2 malaria

Population pharmacokinetics of artemether, lumefantrine and their 1 respective metabolites in Papua New Guinean children with uncomplicated 2 malaria 3 4 Sam Salman, Madhu Page-Sharp, Susan Griffin, Kaye Kose, Peter M. Siba, Kenneth F. 5 Ilett, Ivo Mueller, Timothy M. E. Davis 6 7 School of Medicine and Pharmacology, University of Western Australia, Fremantle 8 Hospital, Fremantle, Western Australia, Australia; School of Pharmacy, Curtin University of 9 Technology, Bentley, Australia; Papua New Guinea Institute of Medical Research, Madang, 10 Papua New Guinea 11 12 *Current addresses: Centre de Recerca en Salut Internacional de Barcelona (CRESIB), 13 Barcelona, Spain and Infection and Immunity Division, Walter and Eliza Hall Institute, 14 Parkville, Victoria, Australia. 15 16 Correspondence and reprints: Professor T. M. E. Davis, University of Western Australia, 17 School of Medicine and Pharmacology, Fremantle Hospital, PO Box 480, Fremantle, 18 Western Australia 6959, Australia. Telephone: +618 9431 3229; Fax: +618 9431 2977; 19 email: [email protected] 20 21 Running head: Artemether-lumefantrine pharmacokinetics in children 22 23 Copyright © 2011, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.05136-11 AAC Accepts, published online ahead of print on 29 August 2011